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INTERNSHIP DETAILS

Summer Intern, Polysaccharide

CompanyVaxcyte

LocationSan Carlos

Work ModeOn Site

PostedFebruary 25, 2026

Internship Information

Core Responsibilities

The intern will receive training in microbiological techniques and analytical assays to support fermentation studies for various S. pneumoniae serotypes, including operating the AMBR system to collect real-time fermentation data. Responsibilities also involve analyzing optical density measurements to support online biomass monitoring and evaluating this system across multiple serotypes for consistency.

Internship Type

full time

Salary Range

$23 - $30

Company Size

511

Visa Sponsorship

Language

English

Working Hours

40 hours

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About The Company

Vaxcyte is a vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases. VAX-31, a 31-valent pneumococcal conjugate vaccine (PCV) candidate being evaluated in a Phase 3 adult clinical program and in a Phase 2 infant clinical program, is being developed for the prevention of invasive pneumococcal disease (IPD) and is the broadest-spectrum PCV candidate in the clinic today. VAX-24, a 24-valent PCV candidate, is designed to cover more serotypes than any infant PCV on-market. VAX-31 and VAX-24 are designed to improve upon standard-of-care PCVs by covering the serotypes in circulation that cause a significant portion of IPD and are associated with high case-fatality rates, antibiotic resistance and meningitis, while maintaining coverage of previously circulating strains. VAX-XL, in earlier-stage development, also leverages the Company’s carrier-sparing, site-specific conjugation technology with the aim of further expanding coverage to deliver the broadest-spectrum candidate in the Company’s PCV franchise. Vaxcyte is re-engineering the way highly complex vaccines are made through XpressCF®, its cell-free protein synthesis platform exclusively licensed from Sutro Biopharma, Inc. Unlike conventional cell-based approaches, the Company’s system for producing difficult-to-make proteins and antigens is intended to accelerate its ability to develop high-fidelity vaccines with enhanced immunological benefits. Vaxcyte’s pipeline also includes VAX-A1, a prophylactic vaccine candidate designed to prevent Group A Strep infections, and VAX-GI, a vaccine candidate designed to prevent Shigella. For more information, visit www.vaxcyte.com.

About the Role

Join our Mission to Protect Humankind!

Vaxcyte is a clinical-stage vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases, which have serious and costly health consequences when left unchecked. Working to eradicate or treat bacterial infections such as invasive pneumococcal disease, Group A Strep, and Shigella is just the beginning. Our path to success is clear and well-defined, and Vaxcyte is set up to go the distance.

WHAT we do is every bit as important as HOW we do it! Our work together is guided by four enduring core values:

*RETHINK CONVENTION: We bring creative and intellectual diversity to every facet of the work we do in order to innovate and re-innovate the way vaccines are delivered.

*AIM HIGH: We embody our collectively audacious goal to courageously make the most complex biologics ever attempted to protect humankind.

*LEAD WITH HEART: Everyone leads at Vaxcyte with a kindness-first, inclusive approach to collaboration and vigorous debate that advances our business objectives.

*MODEL EXCELLENCE: The magnitude of our challenge requires our shared commitment to demonstrating integrity, accountability, equality and clarity across communications and decision making.

Summary:

Vaxcyte’s Summer Internship program offers students with an opportunity to gain valuable work experience that complements their college curriculum with relevant hands-on work that can shape their future career pathing and interests.

As a Polysaccharide Intern for Vaxcyte, you will work on a project as outlined below:

Receive training in microbiological techniques and analytical assays to support fermentation studies for multiple S. pneumoniae serotypes.
Learn to operate the AMBR system to monitor and collect real-time fermentation data.
Analyze and correlate optical density (OD) measurements across multiple systems to support implementation of an online biomass monitoring approach.
Apply proper microbiological handling, data collection, and documentation practices to generate high-quality analytical results.
Evaluate and validate the online biomass monitoring system across multiple serotypes to assess consistency and performance.

The Intern will learn and practice:

Sterile Microbiological Techniques.
Streptococcus pneumonia upstream processes.
Polysaccharide Analytical Assays.
Data Documentation and Reporting.
Independent Research and Problem Solving.
Collaboration and Professional Development.

Program Details:

The Internship will begin in June and will be around 10 weeks (8 hours per day) in duration at our San Carlos, California location.

Requirements:

Must be pursuing a Bachelor’s Degree (enrolled student with at least 1 year at university completed) or Master’s Degree with a focus on Biotechnology, Biochemistry, or Microbiology.
Proficiency in Microsoft Office.
Strong attention to detail and work quality.
Demonstrates collaboration and teamwork.
Enthusiastic-Shows curiosity and is eager to learn.
Dedicated.
This position is for the upstream polysaccharide lab (BSL2) and vaccination against S. pneumoniae is available and recommended.

Reports to: Senior Associate Scientist, Polysaccharide Process Development

Location: San Carlos, CA

Salary Range: The expected salary range for this position is $23-$26 per hour for undergraduate students and $30+/hr for graduate students. Actual pay will be determined based on year of university/college completed. The Summer Internship position will not be eligible for benefits. Relocation and housing stipend will not be offered.

We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status.

Key Skills

Microbiological TechniquesAnalytical AssaysFermentation StudiesAMBR System OperationBiomass MonitoringData AnalysisMicrobiological HandlingData CollectionDocumentation PracticesSterile TechniquesStreptococcus Pneumoniae Upstream ProcessesPolysaccharide Analytical AssaysIndependent ResearchProblem SolvingCollaborationMicrosoft Office