INTERNSHIP DETAILS

Intern, Biophysics & Protein Sciences Group

CompanyRevolution Medicines
LocationRedwood City
Work ModeOn Site
PostedApril 22, 2026
Internship Information
Core Responsibilities
The intern will contribute to the development and evaluation of a small-scale protein expression and purification platform. Responsibilities include executing experiments, analyzing outcomes across various constructs, and providing data-driven recommendations for protocol improvements.
Internship Type
full time
Salary Range
$67,000 - $81,000
Company Size
3
Visa Sponsorship
No
Language
English
Working Hours
40 hours
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About The Company
Revolution Medicine enables physicians to integrate personalized medicine into their practices in order to more effectively treat patients. Our genes play an important role in determining how we respond to about 75% of prescription drugs. Scientific research has demonstrated which genes predict these responses. According to the American Medical Association (AMA), 98% of physicians agree that knowing a patient’s genetic profile would help in prescribing medications. Yet, 90% of physicians do not feel they are adequately informed about how to apply genetic testing to treatment decisions. Our mission is to improve the quality of patient care by helping doctors determine optimal treatment strategies and more accurately predict treatment responses. Revolution Medicine has developed ScriptMatch, an analytical process that enables physicians to easily incorporate genetic testing into their practices. Our company solves a major issue in the clinical market and addresses an emerging trend in patient-driven healthcare: having clinical results that become part of the medical record and applicable to future treatments.
About the Role

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

The Biophysics and Protein Sciences Group generates target proteins to support drug discovery efforts. We currently utilize heterologous overexpression systems, including bacterial and insect cell expression, and purify proteins using a variety of approaches (e.g., bulk purification, FPLC, immunoprecipitation). To maximize our capacity to test multiple construct designs and rapidly determine which proteins can be reliably produced, we are actively developing a small-scale expression and purification (SmScExpPur) platform along with a series of protocols spanning the full workflow: from construct design through small-scale expression testing, purification, and quality control. The summer intern will contribute to this ongoing effort by owning a defined set of experiments aimed at further developing and evaluating SmScExpPur protocols, with the goal of improving protein yield, consistency, and quality. This will include executing small-scale expression and purification experiments, analyzing outcomes across constructs and conditions, and contributing data-driven recommendations for protocol improvements. Proteins generated through this work will be used to perform basic QC assessments to evaluate protein identity, aggregation state, and folding.

Required Skills, Experience and Education:

  • Prior hands-on laboratory experience in an academic or industry setting.

  • Strong attention to detail and experimental rigor.

  • Clear written and verbal communication skills.

  • Experience with basic laboratory techniques, including pipetting.

  • Experience documenting experiments through protocols, laboratory notebooks, laboratory reports, or research papers.

  • Familiarity with bacterial transformation and/or recombinant protein expression workflows.

Preferred Skills:

  • Experience with insect cell expression systems.

  • Experience with protein purification techniques (e.g., affinity purification, FPLC).

  • Interest or experience in protocol development, optimization, or troubleshooting.

  • Experience with liquid handling or semi-automated laboratory systems. 

    #LI-Hybrid  #LI-AP1

The base pay salary range for this intern position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.

Base Pay Salary Range
$67,000—$81,000 USD

We are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message.
 
Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official @revmed.com email address.
 
If you believe you’ve been contacted by someone impersonating a Revolution Medicines recruiter, please report it to careers@revmed.com so we can share these impersonations with our IT team for tracking and awareness.

 

Key Skills
Laboratory techniquesPipettingBacterial transformationRecombinant protein expressionProtein purificationFPLCAffinity purificationInsect cell expressionProtocol developmentTroubleshootingLiquid handlingQuality controlData analysisDocumentationExperimental rigor
Categories
Science & ResearchHealthcareEngineering
Benefits
Competitive cash compensationEquity awardsLearning and development opportunities